Solution 1
Download the attached repair tool and execute
Solution 2
Login as system administrator
Navigate to following folders and provide fulll permissions
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C: >>Program Files >> Quark
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C: >> Program Data >Quark
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C: >>User >> Current user >> Application data >> local >> Quark
Launch QuarkXPress
Solution 3
1. Uninstall QuarkXPress
Reinstall and reactivate.